What question did this study set out to answer?

To assess the expression and subtype distribution of cardiac angiotensin II receptors across developmental stages in genetically cardiomyopathic hamsters.

November 1, 1995Circulation Research

Upregulation of Cardiac Angiotensin II AT1Receptors in Congenital Cardiomyopathic Hamsters

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Authors

CLChantal LambertPennington Biomedical Research Center YMYolette MassillonHôtel-Dieu de Montréal SMSylvain MelocheInstitute for Research in Immunology and Cancer

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Implication

AT1 upregulation precedes lesions in myopathic hamsters; leaves open causal role and therapeutic implications.

Key Points

To assess the expression and subtype distribution of cardiac angiotensin II receptors across developmental stages in genetically cardiomyopathic hamsters.
Analyzed ventricular tissue from embryonic and 25- to 350-day-old control, cardiomyopathic (CHF 146), and heterozygous hamsters.
Conducted radioligand binding assays using 125I-[Sar1,Ile8]Ang II alongside subtype-selective antagonists, including losartan, to determine receptor affinity and density.
Cardiac AT1 receptor density increased by 90% in adult cardiomyopathic hamsters at 70 to 75 days, with significant upregulation detected as early as 25 days before histological lesions appeared.
Losartan binding affinity did not differ significantly between adult normal (mean Kd, 19.6 nmol/L) and cardiomyopathic animals (mean Kd, 16.7 nmol/L), and embryonic hearts exhibited no differences in AT1 and AT2 proportions.

Cite This Study

Lambert et al. (1995) studied this question.

synapsesocial.com/papers/6a72c2728031ec7bb1dd79d8 https://doi.org/10.1161/01.res.77.5.1001

Topics

Cardiomyopathy Cardiac amyloidosis

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Upregulation of Cardiac Angiotensin II AT1Receptors in Congenital Cardiomyopathic Hamsters

Discussion

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Implication

Key Points

Cite This Study

Topics

Upregulation of Cardiac Angiotensin II AT1Receptors in Congenital Cardiomyopathic Hamsters

Discussion

Member takes

Implication

Key Points

Cite This Study

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Topics

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