Why the study?
The study was conducted to assess the features of vascular remodeling according to different activity of renin-angiotensin-aldosterone system components in patients with arterial hypertension and concomitant obesity.
Is low-renin arterial hypertension associated with less vascular remodeling and oxidative stress compared to high-renin arterial hypertension in patients with hypertension and obesity?
Is low-renin arterial hypertension associated with less vascular remodeling and oxidative stress compared to high-renin arterial hypertension in patients with hypertension and obesity?
In patients with hypertension and obesity, low-renin status is associated with less severe vascular remodeling and oxidative stress compared to high-renin status.
Associations between RAAS activity, oxidative stress, and vascular remodeling in obese hypertensives remain hypothesis-generating; prospective studies needed before any clinical application.
The objective: the aim of the study was to assess the features of vascular remodeling indifferent activity of the renin-angiotensin-aldosterone system components in patients with arterial hypertension and concomitant obesity.Materials and methods. We examined 200 patients with arterial hypertension and obesity class I–II who gave informed written consent to participate in the study and met the inclusion criteria.Results. Comparative assessment of oxidative stress – antioxidant defense of obese patients has shown that when they have low arterial arterial hypertension, the levels of oxidative stress indices are significantly lower, and overall antioxidant protection is significantly higher than with high-renin arterial hypertension.Conclusion. As a result of the study, it was established that in patients with comorbidity of arterial hypertension and obesity class I–II, low-renin arterial hypertension was associated with less pronounced impairments incertain vascular remodeling parameters (intima-media thickness in the place of the carotid artery bifurcation and pulse wave velocity in the carotid artery), as well as a greater activity of general antioxidant protection and lower activity of oxidative stress indicators such as malonic dialdehyde and diene conjugates.
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Valentyna Psarova (2019) studied this question.
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