Why the study?
Does pronounced weight loss improve structural alterations in small resistance arteries in obese patients?
Does pronounced weight loss improve structural alterations in small resistance arteries in obese patients?
Obesity induces hypertrophic remodeling and endothelial dysfunction in small resistance arteries, which carry prognostic significance for cardiovascular outcomes and may be reversible with weight loss.
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May support weight loss to reverse obesity-related vascular remodeling; hypothesis-generating pending prospective trials.
Rizzoni et al. (2011) studied this question.
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