Actin interaction with the secondary actin binding site of myosin is specific for the loop 3 sequence of striated muscle myosin isoforms but is not essential for high affinity actin-myosin interface formation or actomyosin ATPase activity modulation.
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Loop 3 confers striated-myosin specificity for actin binding without altering ATPase; extends isoform mapping but leaves cardiac relevance open.
Dijk et al. (1999) studied this question.
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