Population
In vitro model using smooth muscle tropomyosin and actin
Comparison
Addition of skeletal or smooth muscle myosin heads vs Absence of myosin heads or presence of ATP
Design
Preclinical
Authors
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May inform smooth muscle contraction models; hypothesis-generating with no immediate clinical implications.
Myosin heads, both with and without ADP, regulate tropomyosin position, suggesting a mechanism for the regulation of smooth muscle contraction.
Philip Graceffa (1999) studied this question.