Why the study?
The study was conducted to determine the most effective treatment for reducing the incidence of major adverse cardiac events in patients with vasospastic angina.
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Population
Patients with vasospastic angina
Comparison
CCBs with vs without long-acting nitrates
Design
Systematic review and meta-analysis
CCBs alone may suffice to lower MACE in VSA; challenges routine nitrate addition and supports dedicated RCTs.
Background: A systematic review and meta-analysis was conducted to assess the most effective treatment (long-term administration of calcium channel blockers [CCBs] with and without any form of long-acting nitrates [nitrates]) for reducing the incidence of major adverse cardiac events (MACEs) in patients with vasospastic angina (VSA).
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Mizutani et al. (2021) studied this question.
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