Key result
Benidipine was as effective as atenolol in reducing cardiovascular events in post-myocardial infarction patients, with no significant difference in the primary composite outcome (HR 0.64, p=0.276).
Why the study?
Does benidipine reduce cardiovascular events compared to atenolol in post-MI patients without vasospastic angina?
Population
120 post-MI patients, mean age ~60, ~84% male, based in Japan. Key exclusions: AMI within the previous 1…
Comparison
Benidipine 4-8 mg oral once daily vs Atenolol 25-50 mg oral once daily (beta-blocker)
Design
RCT, Randomly assigned, Prospective, randomized, open-label and blinded…
Follow-up
Median 1,124 days
Authors
Loading...
No difference in post-MI events with CCA versus BB; leaves open whether CCA is noninferior and requires prospective confirmation.
RCT (n=120)
Open-label
randomly assigned
Yes
Does benidipine reduce cardiovascular events compared to atenolol in post-MI patients without vasospastic angina?
Hazard Ratio: 0.64 (95% CI 0.284–1.44)
Absolute Event Rate: 16.9% vs 25%
p-value: p=0.276
Nakagomi et al. (2011) conducted an RCT in Post-myocardial infarction (n=120). Benidipine vs. Atenolol 25-50 mg/day was evaluated on Composite of death from cardiovascular events, new onset of angina pectoris and silent myocardial ischemia requiring PCI, or target lesion revascularization (HR 0.64, 95% CI 0.284-1.440, p=0.276). Benidipine was as effective as atenolol in reducing cardiovascular events in post-myocardial infarction patients, with no significant difference in the primary composite outcome (HR 0.64, p=0.276).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: