Why the study?
Do calcium channel blockers improve major cardiovascular outcomes compared with other antihypertensive medications in hypertensive patients with previous stroke and/or CAD?
Population
Hypertensive patients with concomitant previous stroke and/or coronary artery disease from 7 unique trials.
Comparison
Calcium channel blockers (CCBs) vs Other classes of antihypertensive medications
Design
Meta-analysis, Randomized (inclusion criteria for trials)
Follow-up
≥6 months
Key result
In hypertensive patients with CAD, calcium channel blockers reduced stroke risk but increased CHF risk compared to other antihypertensives, with no difference in other major CV outcomes.
Authors
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Clinicians should weigh stroke benefit against CHF risk when choosing CCBs in hypertensive CAD; extends evidence on outcome-specific antihypertensive effects.
Meta-Analysis
Do calcium channel blockers improve major cardiovascular outcomes compared with other antihypertensive medications in hypertensive patients with previous stroke and/or CAD?
In hypertensive patients with CAD, CCBs are associated with a reduced risk of stroke but an increased risk of CHF compared to other antihypertensives, while showing similar efficacy in patients with prior stroke.
Jeffers et al. (2015) conducted a meta-analysis in Hypertension with previous stroke and/or coronary artery disease. Calcium channel blockers vs. Other classes of antihypertensive medications was evaluated on Major cardiovascular outcomes. In hypertensive patients with CAD, calcium channel blockers reduced stroke risk but increased CHF risk compared to other antihypertensives, with no difference in other major CV outcomes.