Why the study?
Do calcium channel blockers reduce the risk of stroke compared to other antihypertensive drugs in hypertensive subjects?
Population
103,793 hypertensive subjects pooled from 13 major studies
Comparison
Calcium channel blockers as a class, including… vs Different/alternative antihypertensive drugs
Design
Meta-analysis
Key result
Calcium channel blockers significantly reduced the risk of stroke compared with other antihypertensive drugs in patients with essential hypertension (OR 0.90; 95% CI 0.84-0.96; P=0.002).
Authors
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Supports preferential CCB use for stroke prevention in essential hypertension; confirms benefit independent of blood pressure reduction.
Meta-Analysis (n=103,793)
Do calcium channel blockers reduce the risk of stroke compared to other antihypertensive drugs in hypertensive subjects?
Effect estimate: OR 0.90 (95% CI 0.84-0.96)
Absolute Event Rate: 4.16% vs 3.71%
p-value: p=0.002
Calcium channel blockers are associated with a significantly lower risk of stroke compared to other antihypertensive drugs in patients with essential hypertension, an effect that appears independent of the degree of systolic blood pressure reduction.
Angeli et al. (2004) conducted a meta-analysis in Essential hypertension (n=103,793). Calcium channel blockers (CCBs) vs. Other antihypertensive drugs was evaluated on Incident cases of stroke (OR 0.90, 95% CI 0.84-0.96, p=0.002). Calcium channel blockers significantly reduced the risk of stroke compared with other antihypertensive drugs in patients with essential hypertension (OR 0.90; 95% CI 0.84-0.96; P=0.002).
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