Key result
Calcium channel blockers significantly reduced the risk of stroke compared with other antihypertensive drugs in patients with hypertension (OR 0.90; 95% CI 0.84-0.96; P=0.002).
Why the study?
Do calcium channel blockers reduce the risk of stroke compared to other antihypertensive drugs in patients with hypertension?
Population
13 studies pooling 103,793 subjects with essential hypertension
Comparison
Calcium channel blockers as a class vs Different antihypertensive drugs
Design
Meta-analysis
Authors
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Supports prioritizing calcium channel blockers for stroke prevention in hypertension; confirms class-specific benefit independent of systolic blood pressure reduction.
Meta-Analysis (n=103,793)
Do calcium channel blockers reduce the risk of stroke compared to other antihypertensive drugs in patients with hypertension?
Odds Ratio: 0.9 (95% CI 0.84–0.96)
Absolute Event Rate: 4.16% vs 3.71%
p-value: p=0.002
Calcium channel blockers significantly reduce the risk of stroke compared to other antihypertensive drugs in patients with hypertension, an effect that appears independent of the degree of systolic blood pressure reduction.
Angeli et al. (2004) conducted a meta-analysis in hypertension (n=103,793). Calcium channel blockers vs. other antihypertensive drugs was evaluated on stroke (OR 0.90, 95% CI 0.84-0.96, p=0.002). Calcium channel blockers significantly reduced the risk of stroke compared with other antihypertensive drugs in patients with hypertension (OR 0.90; 95% CI 0.84-0.96; P=0.002).
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