What question did this study set out to answer?

This research aims to determine how common QT interval prolongation is among medical inpatients and to identify its determinants.

February 8, 2011Internal Medicine JournalOpen Access

Prevalence and determinants of QT interval prolongation in medical inpatients

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Population

537 consecutive patients admitted to the internal medicine ward who had an electrocardiogram performed…

Design

Cross-sectional, Two blinded readers manually measured the QT intervals.

Authors

MPMathieu PasquierInternational Commission on Radiation Units and Measurements OPOlivier PantetUniversity Hospital of Lausanne OHOlivier HügliUniversity Hospital of Lausanne

Discussion

Member takes

Implication

Supports vigilance for QTc risks on admission; hypothesis-generating for prospective outcome trials.

Key Points

This research aims to determine how common QT interval prolongation is among medical inpatients and to identify its determinants.
Enrolled consecutive medical inpatients who had an electrocardiogram within 24 hours of admission.
Measured QT intervals and corrected them using the Bazett and Framingham formulas.
Used logistic regression to identify associations between patient characteristics, drugs, and QTc prolongation.
22.3% of 537 patients showed QTc prolongation using the Bazett formula.
Significantly higher odds of QTc prolongation were found in patients with liver disease (OR 2.9, 95% CI: 1.5-5.6) and hypokalaemia (OR 3.3, 95% CI: 1.9-5.6).
50.8% of patients with QTc prolongation received additional QT-prolonging drugs during hospitalization.

Structured PICO

Population

537 consecutive patients admitted to the internal medicine ward who had an electrocardiogram performed within 24 h of admission.

Outcome

Prevalence of QT prolongation and determinants of this conditionsurrogate

QTc prolongation is highly prevalent among medical inpatients and is strongly associated with liver disease, hypokalemia, and use of QT-prolonging drugs.

Cite This Study

Pasquier et al. (2011) studied this question.

synapsesocial.com/papers/6a72c2e475498292b70bb829 https://doi.org/10.1111/j.1445-5994.2011.02447.x

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Prevalence and determinants of QT interval prolongation in medical inpatients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Prevalence and determinants of QT interval prolongation in medical inpatients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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