Population
Sheep cardiac Purkinje fibres
Comparison
Various concentrations of activator cations to… vs Absence of activator cation or different…
Design
Preclinical
Authors
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Clarifies Na pump-cation effects on twitch tension in fibres; extends mechanistic insights but leaves open relevance to intact hearts.
In sheep cardiac Purkinje fibres, the effects of activator cations on twitch tension are determined by their activation of the Na pump and subsequent effects on internal sodium concentration.
Eisner et al. (1980) studied this question.
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