Opsoclonus-myoclonus syndrome as a post-infectious complication of COVID-19

Opsoclonus is the irregular, arrhythmic, and chaotic eye movements in all directions of gaze, and it is frequently accompanied by ataxia, encephalopathy, and myoclonus. Accordingly, the term “opsoclonus-myoclonus syndrome” (OMS) has been introduced. Opsoclonus-myoclonus syndrome is a rare and heterogeneous neurological condition caused by infections, malignancies, toxic and metabolic disorders. Immune mechanisms are associated with OMS. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the disease has many neurological manifestations. Opsoclonus-myoclonus syndrome can manifest in consequence of this infectious disease as a parainfectious condition. In this article, we report two cases of OMS developed after SARS-CoV-2 infection.