Why the study?
Does mechanical stress activate a protein kinase cascade involving angiotensin II in cardiocytes?
Population
In vitro system of cardiocytes (cardiac myocytes)
Comparison
Mechanical stress with or without CV11974 vs Unstretched cardiocytes or stretched cardiocytes…
Design
Preclinical
Authors
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Stretching activates Raf-1/MAPK signaling partly via Ang II in cardiocytes; leaves open in vivo relevance to hypertrophy and any clinical translation.
Does mechanical stress activate a protein kinase cascade involving angiotensin II in cardiocytes?
Mechanical stress activates a protein kinase cascade in cardiocytes that is partially mediated by locally produced angiotensin II, providing insight into the molecular mechanisms of cardiac hypertrophy.
Kumuro et al. (1995) studied this question.
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