Why the study?
Does acute modulation of endothelial Akt activity alter nitric oxide-dependent vasomotor activity in vivo?
Population
Rabbit femoral artery model and murine aorta ex vivo
Comparison
Endothelial infection with replication-defective… vs Adenoviral construct expressing beta-galactosidase
Design
Preclinical
Authors
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Endothelial Akt acutely regulates NO-dependent vasomotor tone in vivo; extends mechanistic data but leaves open human translation.
Does acute modulation of endothelial Akt activity alter nitric oxide-dependent vasomotor activity in vivo?
Akt functions as a key regulator of vasomotor tone in vivo by enhancing nitric oxide-dependent vasomotor activity.
Luo et al. (2000) studied this question.
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