A New Mediator for an Old Hormone?

It is well established that estrogen mediates many of its physiological actions by binding to estrogen receptors in the nucleus, which then activate the transcription of target genes. However, as [Hewitt, Deroo and Korach][1] discuss in their Perspective, new work reveals that some of estrogen's effects may be mediated by a nonclassical pathway in which estrogen binds to non-estrogen receptor membrane proteins such as GPR30 ([ Revankar et al .][2]). [1]: http://www.sciencemag.org/cgi/content/full/307/5715/1572 [2]: http://www.sciencemag.org/cgi/content/short/307/5715/1625