Population
Anaesthetized mice
Comparison
Tolbutamide or diazoxide injection vs Untreated animals / control state
Design
Preclinical
Follow-up
10 min after injection
Authors
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Hypothesis-generating for beta-cell K(ATP) modulation in rodents; leaves open translation to human diabetes management.
In vivo, tolbutamide and diazoxide have direct and opposite effects on the electrical activity of pancreatic beta-cells, modulating K(ATP) channels and explaining their hypo- and hyperglycaemic effects.
Gomis et al. (1998) studied this question.
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