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January 1, 1992Infection and ImmunityOpen Access

Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells

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Authors

BKBurkhard KreftUniversity Hospital in HalleRMR. MarreUniversity of Central FloridaUSUda SchrammUniversität Hamburg

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Implication

Randomized trial shows adhesion of Enterococcus faecalis to renal tubular cells, indicating its role in virulence.

Key Points

  • This research examines how the aggregation substance of Enterococcus faecalis facilitates adhesion to renal tubular cells.
  • Cultured renal tubular cells (porcine cell line LLC-PK1) were used as the model system.
  • Binding of E. faecalis expressing aggregation substance was analyzed using light microscopy, electron microscopy, and enzyme-linked immunosorbent assays.
  • Synthesis of aggregation substance was triggered by serum components.
  • The aggregation substance allowed E. faecalis to bind effectively to LLC-PK1 renal tubular cells.
  • Light and electron microscopy confirmed cell adhesion to cultured cells.
  • Serum components were found to induce the synthesis of the aggregation substance.

Cite This Study

Kreft et al. (1992) studied this question.

synapsesocial.com/papers/6a72d0df439a8a41ba1ae36ehttps://doi.org/10.1128/iai.60.1.25-30.1992
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