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June 15, 2020Cardiovascular DiabetologyOpen Access

Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study

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Why the study?

The role of right ventricular and right atrial structure and function in the increased heart failure risk in (pre)diabetes is incompletely understood.

Is (pre)diabetes associated with changes in right ventricular and atrial structure and function compared to normal glucose metabolism?

Population

426 NGM, 142 prediabetes, and 224 diabetes participants in the Maastricht Study

Comparison

Prediabetes and diabetes vs NGM

Design

Population-based cohort study

Authors

PLPauline B. C. LinssenMVMarja G. J. VeugenRHRonald M.A. Henry

Discussion

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Overview

May signal early RV/RA remodeling contributing to HF risk in (pre)diabetes; leaves open mediation by LV changes and need for prospective confirmation.

Structured PICO

Is (pre)diabetes associated with changes in right ventricular and atrial structure and function compared to normal glucose metabolism?

P
Population
792 participants of the Maastricht Study (a population-based cohort), including 426 with normal glucose metabolism (NGM), 142 with prediabetes, and 224 with diabetes.
I
Intervention
Prediabetes and diabetes
C
Comparator
Normal glucose metabolism (NGM)
O
Outcome
Right ventricular (RV) and right atrial (RA) structure and function measured by two-dimensional and tissue Doppler echocardiographysurrogate

(Pre)diabetes is associated with structural and functional changes in the right atrium and right ventricle that appear to be due to direct myocardial involvement rather than secondary to left ventricular changes.

Cite This Study

Linssen et al. (2020) studied this question.

synapsesocial.com/papers/6a72d1b4d8e6791e255437afhttps://doi.org/10.1186/s12933-020-01055-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subclinical right ventricular dysfunction in diabetes mellitus—an ultrasonic strain/strain rate study2007 · 67 citations
  2. 2Right Ventricular Involvement in Diabetic Cardiomyopathy2012 · 73 citations
  3. 3Impact of Myocardial Acceleration during Isovolumic Contraction in Evaluating Subclinical Right Ventricular Systolic Dysfunction in Type 2 Diabetes Mellitus Patients2010 · 21 citations
  4. 4Detection of occult right ventricular dysfunction in young Egyptians with type 1 diabetes mellitus by two-dimensional speckle tracking echocardiography2018 · 21 citations
  5. 5Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography2009 · 124 citations