The presence of myosin-rich filaments in regions known to contain actin filaments suggests that these proteins interact to generate the motive force in nonmuscle contractile systems.
Suggests actomyosin interaction in nonmuscle motility; leaves open functional validation and human disease relevance.
The distribution of intracellular myosin was studied by the double antibody immunofluorescence method in primary organotypic neuronal cultures and two established neuronal and glial cell lines. An array of parallel filaments aligned with the major cellular axis and a three-dimensional subsurface network were shown to react with two different myosin antibodies. The presence of myosin-rich filaments in regions known to contain actin filaments suggests that these proteins interact to generate the motive force in nonmuscle contractile systems.
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Roisen et al. (1978) studied this question.
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