Population
Rat liver microsomes and microsomes from various sources
Design
Preclinical
Authors
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Challenges assumed P-450 role in demethylation; leaves open oxidase identity with no clinical translation from animal data.
The study provides biochemical evidence that cytochrome P-450 is likely not the terminal oxidase involved in the aerobic hydroxylation of the methyl group during 4-methylsterol demethylation.
Gaylor et al. (1968) studied this question.
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