Key result
Oral H2-receptor antagonists fail to improve LV systolic function or exercise capacity in heart failure.
Why the study?
The effects of cimetidine, famotidine, and ranitidine on left ventricular systolic function, aerobic metabolic performance, and exercise capacity in patients with chronic, stable heart failure required evaluation.
Do oral H2-receptor antagonists (cimetidine, famotidine, ranitidine) affect left ventricular systolic function and exercise capacity in men with chronic stable heart failure?
RCT (n=12)
Double-blind
Randomized, four-way crossover
No
Do oral H2-receptor antagonists (cimetidine, famotidine, ranitidine) affect left ventricular systolic function and exercise capacity in men with chronic stable heart failure?
Short-term administration of H2-receptor antagonists at clinical dosages does not significantly affect left ventricular systolic function or exercise capacity in men with stable heart failure.
Answers are grounded in this paper and cite their sources.
Supports safe short-term H2RA use in stable HF without cardiac concern; confirms neutrality on LV function in this RCT.
Study Objective. To evaluate the effect of cimetidine, famotidine, ranitidine, and placebo on left ventricular systolic function, aerobic metabolic performance, and exercise capacity in patients with chronic, stable heart failure. Design. Double‐blind, randomized, placebo‐controlled, four‐way crossover study. Setting. Outpatient, university‐affiliated cardiology clinic. Patients. Twelve men with stable New York Heart Association class II or III heart failure secondary to ischemic heart disease or hypertension. Interventions. Patients received in random sequence cimetidine 400 mg twice/day, famotidine 40 mg/day, ranitidine 150 mg twice/day, and placebo. Each treatment was administered for 7 days, and the periods were separated by a 1‐week washout. Measurements and Main Results. Before and after each treatment, patients underwent a bicycle stress echocardiogram with aerobic metabolic assessment. Left ventricular function was evaluated by calculating ejection phase indexes from Doppler echocardiographic measurements. All 12 patients successfully completed the study. No patient reported any adverse effect attributed to study drugs. None of the treatments was associated with significant changes in any measure of left ventricular systolic function, aerobic metabolic performance, or exercise capacity, nor were placebo‐subtracted differences for the agents significantly different for any of the three measures.
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Lucas et al. (1998) conducted an RCT in Chronic stable heart failure (n=12). Oral H2-receptor antagonists (cimetidine, famotidine, ranitidine) vs. Placebo was evaluated on Left ventricular systolic function, aerobic metabolic performance, and exercise capacity. Oral H2-receptor antagonists (cimetidine, famotidine, ranitidine) for 7 days produced no significant changes vs placebo in LV systolic function or exercise capacity in 12 men with heart failure.
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