BACKGROUND: Seizures and status epilepticus can occur within 14 days following administration of inactivated and live-attenuated vaccines. These vaccine-proximate seizures can undermine parental confidence in vaccine safety and affect further vaccination decisions. Vaccine-proximate status epilepticus (VP-SE) is uncommon but may be the first manifestation of genetic developmental epileptic encephalopathies, including Dravet syndrome. OBJECTIVE: The aim of this article is to review current literature on the risks and outcomes of vaccine-proximate seizures and, using two clinical scenarios, outline management of subsequent revaccination. DISCUSSION: Vaccine-proximate seizures require careful evaluation of the vaccine(s) involved, seizure type and duration to determine a safe course for revaccination. Vaccine-proximate febrile seizures (VP-FSs) have similar outcomes to other febrile seizures and are not associated with increased developmental or behavioural concerns. Vaccination for children with VP-FSs can occur safely in the community. However, VP-SE cases warrant prompt specialist review, consideration of genetic epilepsy testing and referral to a specialist immunisation clinic for subsequent vaccination under medical supervision.
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Deng et al. (2020) studied this question.
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