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January 1, 2015BioMed Research InternationalOpen Access

Filament Dynamics during Simulated Ventricular Fibrillation in a High-Resolution Rabbit Heart

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Population

High-resolution biventricular rabbit heart model

Design

Preclinical

Authors

PPPras PathmanathanUnited States Food and Drug AdministrationRGRichard A. GrayCenter for Devices and Radiological Health

Discussion

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Overview

Anatomy-driven VF complexity in rabbit models warrants clinical caution; leaves open human translation pending validation.

Structured PICO

P
Population
High-resolution biventricular rabbit heart model
I
Intervention
Simulated ventricular fibrillation
O
Outcome
3D filament dynamics and intramural electrical activity

Computational modeling of a rabbit heart reveals that 3D intramural electrical activity during ventricular fibrillation is extraordinarily complex and heavily influenced by anatomical structures.

Cite This Study

Pathmanathan et al. (2015) studied this question.

synapsesocial.com/papers/6a72dca44618153781543bcfhttps://doi.org/10.1155/2015/720575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Filament Behavior in a Computational Model of Ventricular Fibrillation in the Canine Heart2004 · 31 citations
  2. 2Organization of Ventricular Fibrillation in the Human Heart2007 · 163 citations
  3. 3Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation1998 · 863 citations
  4. 4Ventricular fibrillation in myopathic human hearts: mechanistic insights from in vivo global endocardial and epicardial mapping2007 · 104 citations
  5. 5Dynamics of Intramural and Transmural Reentry During Ventricular Fibrillation in Isolated Swine Ventricles2001 · 127 citations