May 10, 2019Lipids in Health and DiseaseOpen Access

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway

View Full Paper

Ask AI

Bookmark

Why the study?

Metformin is associated with a decreased risk of AF in patients with type 2 diabetes, but the specific underlying mechanism remains unknown.

Does metformin prevent lipid metabolic remodeling in a canine model of atrial fibrillation?

Comparison

SR vs ARP vs ARP plus MET

Design

Preclinical animal study

Authors

FBFan BaiHunan University of Traditional Chinese Medicine YLYaozhong LiuTulane University TTTao TuUniversity of Science and Technology of China

Discussion

Member takes

Implication

Metformin modulates atrial FA metabolism via AMPK in canine AF; leaves open whether this translates to human AF prevention.

Structured PICO

Does metformin prevent lipid metabolic remodeling in a canine model of atrial fibrillation?

Population

15 mongrel dogs

Intervention

Metformin (100 mg/kg/day) for two weeks before atrial rapid pacing (800 beats/min for 6 h)

Comparator

Sinus rhythm (SR) group and atrial rapid pacing (ARP) group without metformin

Outcome

Metabolic factors, speed limiting enzymes, circulating biochemical metabolites, atrial electrophysiology, and accumulation of lipid dropletssurrogate

Metformin reduces lipid accumulation and promotes fatty acid β-oxidation in a canine model of atrial fibrillation, suggesting a mechanism for its protective effects against AF.

Cite This Study

Bai et al. (2019) studied this question.

synapsesocial.com/papers/6a72dcc2a238d4636f543b72 https://doi.org/10.1186/s12944-019-1059-7

Topics

Persistent AF management Atrial fibrillation

View Full Paper

Ask AI

Bookmark

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider