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December 1, 1983Journal of Clinical InvestigationOpen Access

Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta.

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Authors

DDDavid L. DeWittUniversity of Seoul JDJeffrey S. DayEli Lilly (United States)WSW. K. SonnenburgUniversity of Washington

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Implication

May support PGI2 supplementation to limit platelet adhesion after injury; leaves open its endogenous role in human thrombosis.

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Cite This Study

DeWitt et al. (1983) studied this question.

synapsesocial.com/papers/6a72dcd3beb211e5dcf3cf93 https://doi.org/10.1172/jci111151

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Prostacyclin (prostaglandin I2, PGI2) inhibits platelet adhesion and thrombus formation on subendothelium1979 · 175 citations
2Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.1976 · 438 citations
3Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells.1981 · 165 citations
4Synthesis of Antihemophilic Factor Antigen by Cultured Human Endothelial Cells1973 · 1,291 citations
5The Prostaglandin Forming Cyclooxygenase of Ovine Uterus: Relationship to Luteal Function1979 · 70 citations