Utilizing a syngeneic tumor-host system, the role of the regional lymph node in initiating immunity to tumor was evaluated. In the absence of regional lymph nodes, no apparent sinecomitant nor concomitant immunity developed despite the presence of a growing immunizing tumor for as long as 28 days. Findings minimize the role of the bloodstream in host sensitization to tumor. They provide another possible explanation as to why an antigenic tumor may arise de novo in an immunologically normal host, and they indicate that the regional lymph node is more important in the development of tumor immunity than in production of transplantation or hypersensitivity response.
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Fisher et al. (1971) studied this question.
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