What question did this study set out to answer?

This research investigates how distension in the pulmonary vein-atrial junction affects the activity of left atrial receptors in dogs.

December 1, 1978The Journal of PhysiologyOpen Access

The effect of distension of the pulmonary vein‐atrial junction on activity of left atrial receptors

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Why the study?

Does distension of the pulmonary vein-atrial junction increase the activity of left atrial receptors in anaesthetized dogs?

Population

19 anaesthetized dogs

Comparison

Distension of small balloons in the pulmonary… vs Baseline or normal size atrium

Design

Preclinical

Authors

CKC. KiddRenishaw (United Kingdom)JLJ. R. LedsomeUniversity of Leeds RLR. J. LindenLeeds General Infirmary

Discussion

Member takes

Implication

Animal data link pulmonary vein distension to atrial receptor firing in dogs; leaves open any role in human cardio-renal control.

Key Points

This research investigates how distension in the pulmonary vein-atrial junction affects the activity of left atrial receptors in dogs.
Examined left atrial receptor activity in anaesthetized dogs during balloon distension and pulsatile pressure application.
Identified 11 receptor fibres among 19 dogs, located in the atrial endocardium.
Measured discharge of action potentials in response to different pressures and balloon inflations.
Balloon distension significantly increased action potential discharge rates from left atrial receptors.
Dynamic thresholds for pulsatile pressure were high in the perfused pouch, returning to normal after atrial restoration.
Increased receptor activity is linked to elevated heart rate and urine flow, aligning with previous findings.

Structured PICO

Does distension of the pulmonary vein-atrial junction increase the activity of left atrial receptors in anaesthetized dogs?

Population

19 anaesthetized dogs

Intervention

Distension of small balloons in the pulmonary veins or application of pulsatile pressures to an isolated perfused pouch of the left atrium

Comparator

Baseline or normal size atrium

Outcome

Activity (discharge of action potentials) from left atrial receptors with vagal afferent fibressurrogate

Distension of the pulmonary vein-atrial junction increases left atrial receptor discharge, which may mediate increases in heart rate and urine flow.

Cite This Study

Kidd et al. (1978) studied this question.

synapsesocial.com/papers/6a72e37ea238d4636f543e78 https://doi.org/10.1113/jphysiol.1978.sp012581

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The effect of distension of the pulmonary vein‐atrial junction on activity of left atrial receptors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The effect of distension of the pulmonary vein‐atrial junction on activity of left atrial receptors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider