A surface glycophosphoprotein expressed on developmentally early lymphohematopoietic stem and progenitor cells,"3 small-vessel endothelial and embryonic fibroblasts6 CD34+ bone marrow (BM) cells comprise only 1.5% of marrow mononuclear cells, but contain precursors for all lymphohematopoietic lineages, as evidenced by the finding that CD34+ cells purified from marrow can reconstitute hematopoiesis of primates, humans, or mice undergoing autologous marrow reinfusion after myeloablative therapy (BM tran~plant~-~.""). CD34+ hematopoietic cells obtained from marrow or blood are in clinical use in transplantation and gene therapy studies, including ongoing attempts to expand hematopoietic stedprogenitor cells ex vivo. Despite the importance of CD34 as a marker of early hematopoietic stedprogenitor cells in experimental and clinical hematopoiesis, the function of CD34 is not yet clear. Because of its potential role in such fundamental processes as hematopoietic stedprogenitor cell development and inflammation, studies on the regulation and function of CD34 are being pursued in several laboratories.
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Krause et al. (1996) studied this question.