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February 1, 1974Proceedings of the National Academy of SciencesOpen Access

A Colinear Map Relating the Simian Virus 40 (SV40) DNA Segments of Six Adenovirus-SV40 Hybrids to the DNA Fragments Produced by Restriction Endonuclease Cleavage of SV40 DNA

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Population

Adenovirus-SV40 hybrids and SV40 DNA

Design

Preclinical

Authors

PLPaul LebowitzNational Institutes of HealthTKThomas J. KellyUniversity of FloridaDNDaniel NathansNorthwestern University

Discussion

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Implication

Maps SV40 determinants in hybrids; leaves open any translational relevance to human disease models.

Structured PICO

P
Population
Adenovirus-SV40 hybrids and SV40 DNA
I
Intervention
Nucleic acid hybridization and heteroduplex DNA molecule analysis by electron microscopy using restriction endonuclease cleavage fragments
O
Outcome
Alignment of the map of the SV40 segments of the hybrid viruses with the H. influenzae and H. parainfluenzae cleavage maps of SV40

This study successfully mapped SV40 DNA segments in adenovirus-SV40 hybrids, enabling the localization of genetic determinants for SV40-specific antigens.

Cite This Study

Lebowitz et al. (1974) studied this question.

synapsesocial.com/papers/6a72e651a238d4636f543fd3https://doi.org/10.1073/pnas.71.2.441
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mapping of Simian Virus 40 Early Functions on the Viral Chromosome1973 · 109 citations
  2. 2Preferred Site for Initiation of RNA Transcription by Escherichia coli RNA Polymerase Within the Simian Virus 40 DNA Segment of the Nondefective Adenovirus-Simian Virus 40 Hybrid Viruses Ad2 + ND 1 and Ad2 + ND 31973 · 54 citations
  3. 3Evidence for a Transcription-Control Region of Simian Virus 40 in the Adenovirus 2—Simian Virus 40 Hybrid, Ad2 + ND 11972 · 30 citations
  4. 4Nucleotide Sequence of a Ribonucleic Acid Transcribed in Vitro from λ Phage Deoxyribonucleic Acid1971 · 181 citations
  5. 5A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells.1967 · 1,329 citations