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August 5, 2026BMC MicrobiologyOpen Access

Genomic insights into azole resistance in Aspergillus fumigatus: findings from global and South African clinical isolates

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Authors

SMSiphiwengesihle Kuhle Silindile MbamaliNMNikwando MohlomiMNMagriet A. van der Nest

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Overview

Randomized trial analyzes azole resistance in Aspergillus fumigatus, indicating complex genetic contributions in South Africa.

Key Points

  • This research aims to understand the genetic factors contributing to azole resistance in Aspergillus fumigatus.
  • Analyzed 12 newly sequenced clinical isolates from KwaZulu-Natal, South Africa.
  • Used a uniform workflow for variant calling and genome-wide association studies (GWAS).
  • Filtered SNP-alignment matrix to test for associations between SNPs and azole susceptibility.
  • 194 of 227 genomes met quality thresholds, identifying 31,949 biallelic SNPs.
  • 16 SNPs exceeded the Bonferroni threshold while 206 passed BH-FDR correction, showing resistance is spread across multiple regions.
  • Transporter analysis indicated South African isolates had negative CDR1 and MFS scores, suggesting they have low transporter functionality.

Cite This Study

Mbamali et al. (2026) studied this question.

synapsesocial.com/papers/6a72e79c226790f370656e7ehttps://doi.org/10.1186/s12866-026-05293-0
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Also Consider

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  1. 1Identification and characterization of non-canonical azole antifungal resistance pathways in Aspergillus fumigatus2026
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  4. 4Understanding multi-azole resistance in Aspergillus fumigatus: the impact of non-cyp51A mutation and efflux pump overexpression2026
  5. 5Molecular and Phenotypic Characterization of Multidrug-Resistant Aspergillus fumigatus Clinical Isolates in Republic of Korea2026