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August 5, 2026Schizophrenia Research CognitionOpen Access

Cognitive rehabilitation with immersive virtual reality in schizophrenia: A randomized waiting list-controlled study

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Authors

CCClaudio CaiazzaRegione CampaniaAAAlessia AlettoASL RomaLFLuigi FranzeseASL Roma

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Implication

Randomized trial assesses cognitive rehabilitation effects in schizophrenia, suggesting potential benefits for negative symptoms and psychomotor speed.

Key Points

  • The study evaluates the feasibility, acceptability, and efficacy of immersive virtual reality-based cognitive rehabilitation in schizophrenia.
  • Single-blind, randomized, waiting list controlled trial (NCT07427485).
  • Forty clinically stable outpatients were allocated 1:1 to IVR or WL for 12 weeks.
  • Intervention utilized the CEREBRUM-VR tool to deliver sessions.
  • 15% drop-out rate with 4.9% attrition; 77.8% of IVR participants expressed willingness to continue.
  • Significant improvements for negative symptoms (p < 0.01) and psychomotor speed (SRT p = 0.01, CRT p = 0.01).
  • Nonsignificant changes in GAF and TMT-A; mild adverse effects reported.

Cite This Study

Caiazza et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7c1226790f370656ed7https://doi.org/10.1016/j.scog.2026.100458
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