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August 5, 2026Clinical and Experimental HypertensionOpen Access

Early prediction of preeclampsia among the advanced-age pregnant women: A retrospective multicenter study

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Authors

AHAndong HeXLXiaojun LiKYKa Cheuk Yip

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Overview

Retrospective multicenter study demonstrates an effective nomogram for assessing preeclampsia risk in advanced-age women, indicating improved management possibilities.

Key Points

  • To develop and validate a nomogram for early prediction of preeclampsia among advanced-age pregnant women.
  • Retrospective multicenter study involving 2,582 advanced-age pregnant women from three tertiary centers in China.
  • Participants were divided into training (1,327) and validation cohorts (569, 399, 287).
  • Predictors were selected via LASSO and multivariable logistic regression, with performance evaluated by AUC and calibration.
  • The nomogram identified seven independent predictors of preeclampsia: pre-pregnancy BMI, parity, mode of conception, uric acid, white blood cell count, red blood cell count, and hemoglobin.
  • The nomogram demonstrated AUCs of 0.819, 0.795, 0.787, and 0.756 across the four cohorts, showing close calibration.
  • Including women with chronic hypertension did not affect the performance, and maternal age was non-discriminative (P = 0.626).

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7e2226790f3706572bchttps://doi.org/10.1080/10641963.2026.2713198
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