What question did this study set out to answer?

This review aims to assess the efficacy and safety of teclistamab monotherapy in patients with relapsed or refractory multiple myeloma.

August 5, 2026Hematology ReportsOpen Access

Teclistamab Monotherapy in Relapsed or Refractory Multiple Myeloma: A Real-World Focused Systematic Review and Meta-Analysis of Efficacy and Safety

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Authors

JQJerry QiLoma Linda University Medical Center DPDaniel ParkThe University of Melbourne PSP. ShahLoma Linda University Medical Center

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Implication

Systematic review evaluates teclistamab monotherapy efficacy in relapsed or refractory multiple myeloma, indicating significant clinical activity with manageable toxicity.

Key Points

This review aims to assess the efficacy and safety of teclistamab monotherapy in patients with relapsed or refractory multiple myeloma.
Conducted a systematic review and meta-analysis of clinical trials and real-world studies on teclistamab monotherapy in RRMM
Analyzed 12 studies, including 2 clinical trials and 10 retrospective cohorts, totaling 761 patients
Evaluated outcomes such as overall response rate, complete response, and various mortality rates.
Pooled overall response rate (ORR) was 60.9%
Pooled complete response (CR) rate was 25.2%
Adverse event-related mortality was 8.1%, and grade ≥3 infections occurred in 28.3%.

Cite This Study

Qi et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7e2226790f3706573ed https://doi.org/10.3390/hematolrep18040054

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Implication

Systematic review evaluates teclistamab monotherapy efficacy in relapsed or refractory multiple myeloma, indicating significant clinical activity with manageable toxicity.

Teclistamab Monotherapy in Relapsed or Refractory Multiple Myeloma: A Real-World Focused Systematic Review and Meta-Analysis of Efficacy and Safety

Discussion

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Implication

Key Points

Cite This Study

Teclistamab Monotherapy in Relapsed or Refractory Multiple Myeloma: A Real-World Focused Systematic Review and Meta-Analysis of Efficacy and Safety

Discussion

Member takes

Implication

Key Points

Cite This Study

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