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August 5, 2026Chemistry - A European Journal

Metal‐Based Combination Therapies in Cancer: Mechanistic Principles and Emerging Opportunities

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Authors

XXXinhua XiongZhejiang Academy of Social SciencesJRJiajun RenZhejiang Academy of Social SciencesHWHaibo WangState Key Laboratory of Synthetic Chemistry

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Implication

Review summarizes advances in metal-based combinations for cancer, exploring mechanisms and therapeutic potential.

Key Points

  • This review aims to summarize recent advances in metal-based anticancer combination therapies and their mechanistic principles. It explores how these therapies can enhance treatment efficacy and overcome resistance.
  • Categorized combinations of metal-based agents with distinct chemotherapeutics based on mechanistic functions.
  • Discussed immunomodulatory effects of metallodrugs in combination with immune checkpoint inhibitors.
  • Examined multimodal strategies involving metal-based systems for energy-responsive therapies.
  • Metal-based combinations effectively reinforce DNA damage and improve apoptotic responses.
  • Metallodrugs can induce immunogenic cell death, enhancing anti-tumor immunity when combined with checkpoint blockers.
  • Emerging strategies utilizing energy-responsive metal systems show promise for integration with photodynamic and thermal therapies.

Cite This Study

Xiong et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7e2226790f37065745dhttps://doi.org/10.1002/chem.71514
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