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August 5, 2026Stroke and Vascular NeurologyOpen Access

Lycium barbarum glycopeptide attenuates ischaemic stroke by inhibiting inflammation via SIRT3-mediated NLRP3 deacetylation

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Authors

BHBo HanCMChangsheng MaLZLiying Zhang

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Overview

Randomized trial demonstrates reduced inflammation in ischaemic stroke using glycopeptide treatment, suggesting therapeutic potential.

Key Points

  • This research investigates how Lycium barbarum glycopeptide (LbGP) influences neuroinflammation after ischaemic stroke.
  • Utilized a mouse model of middle cerebral artery occlusion/reperfusion to induce ischaemia.
  • Conducted various tests including Y-maze and open-field for assessing neurological recovery.
  • Analyzed molecular mechanisms via Western blotting, ELISA, co-immunoprecipitation, and immunofluorescence.
  • LbGP significantly reduced cerebral infarct volume and improved functional recovery after I/R injury.
  • It inhibited NLRP3 inflammasome activation through SIRT3-mediated deacetylation of NLRP3.
  • Neuroinflammation was exacerbated in Sirt3-knockout mice, validating the role of SIRT3.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/6a72e7f4226790f37065748bhttps://doi.org/10.1136/svn-2026-005321
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