What question did this study set out to answer?

This study aims to develop a mathematical framework for designing drug delivery systems with specific release profiles.

August 5, 2026Pharmaceutical ResearchOpen Access

Engineering Diffusion-Controlled Drug Delivery Systems to Achieve a Desired Drug Release Profile: Mathematical Modelling and Optimisation

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Randomized trial demonstrates achieving tailored drug release profiles in treatment systems, suggesting improved therapeutic outcomes.

This study aims to develop a mathematical framework for designing drug delivery systems with specific release profiles.
Developed a mathematical model for diffusion-controlled drug release from spherical microcapsules.
Utilized a hybrid imperialist competitive algorithm for inverse optimisation.
Applied the framework to design problems for constant and targeted drug release profiles.
Achieved a constant release rate by optimizing initial drug distribution and selecting appropriate diffusivity.
Found that diverse release profiles require optimising both diffusivity and initial drug loading.

Peri et al. (2026) studied this question.

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