H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis—A Secondary Analysis of the SISPCT Randomized Control Trial

Caroline Neumann; Frank Bloos; Teddy Tun Win Hla; Thomas Bygott; Holger Bogatsch; Michael Kiehntopf; Friedemann Börner; Adrian T. Press; Michael Bauer; A. L. Retter; for the SepNet Critical Care Trials Group

doi:10.1097/ccm.0000000000007270

August 3, 2026Critical Care Medicine

H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis—A Secondary Analysis of the SISPCT Randomized Control Trial

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Key Points

This analysis aims to determine if plasma H3.1 nucleosome levels can serve as predictive biomarkers for renal replacement therapy requirements and mortality in sepsis.
Secondary analysis of multicenter SISPCT trial data
Evaluated 971 sepsis patients for plasma H3.1 levels
Utilized multivariable Cox regression to analyze associations with mortality and RRT.
Higher admission H3.1 levels in septic shock vs. sepsis (921.84 vs. 432.71 ng/mL; p < 0.001)
Each log10 increase in H3.1 associated with 48% increased risk of 28-day mortality (HR, 1.48; 95% CI, 1.07-2.04; p = 0.02)
An increase in H3.1 also raises the risk of requiring RRT by 80% (HR, 1.8; 95% CI, 1.34-2.40; p < 0.001).

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Implication

Secondary analysis reveals H3.1 nucleosome levels predict renal replacement therapy needs and mortality in sepsis patients, suggesting important clinical implications.

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Cite This Study

Neumann et al. (2026) studied this question.

synapsesocial.com/papers/6a72e823226790f370657ac4 https://doi.org/10.1097/ccm.0000000000007270

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H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis—A Secondary Analysis of the SISPCT Randomized Control Trial

Key Points

No abstract yet

Implication

Discussion

Cite This Study

H3.1 Nucleosomes to Predict Renal Replacement Therapy and Mortality in Sepsis—A Secondary Analysis of the SISPCT Randomized Control Trial

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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