What question did this study set out to answer?

The study aims to explore the effects of nandrolone decanoate and exercise on cognitive functions and the underlying mechanisms in rats.

August 5, 2026BiologyOpen Access

Aerobic and Resistance Exercise Modalities Ameliorate Hippocampal Plasticity and Neurocognitive Changes Induced by Receiving Nandrolone Decanoate in Rats (Physiological, Biochemical, and Histological Study)

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Authors

WAWesam M. R. AshourZagazig University AKAbeer A. KhalefaZagazig University LALamiaa A. AhmedAin Shams University

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Implication

Randomized trial investigates effects of aerobic and resistance exercise on cognitive functions in rats, suggesting exercise may mitigate steroid-induced impairments.

Key Points

The study aims to explore the effects of nandrolone decanoate and exercise on cognitive functions and the underlying mechanisms in rats.
Adult male rats divided into control, ND-treated, exercise, and combined ND + exercise groups.
Aerobic and resistance exercises were performed for 8 weeks.
Cognitive evaluations conducted using Modified Barnes Maze and T-maze tests.
ND impaired spatial learning and memory, increased oxidative stress, and reduced BDNF and NGF levels (p<0.01).
Aerobic exercise significantly restored cognitive function and increased BDNF and NGF levels (p<0.05).
Resistance exercise also showed neuroprotective effects but was less effective than aerobic exercise.

Cite This Study

Ashour et al. (2026) studied this question.

synapsesocial.com/papers/6a72e823226790f370657b08 https://doi.org/10.3390/biology15151274

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Implication

Randomized trial investigates effects of aerobic and resistance exercise on cognitive functions in rats, suggesting exercise may mitigate steroid-induced impairments.

Aerobic and Resistance Exercise Modalities Ameliorate Hippocampal Plasticity and Neurocognitive Changes Induced by Receiving Nandrolone Decanoate in Rats (Physiological, Biochemical, and Histological Study)

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Key Points

Cite This Study

Aerobic and Resistance Exercise Modalities Ameliorate Hippocampal Plasticity and Neurocognitive Changes Induced by Receiving Nandrolone Decanoate in Rats (Physiological, Biochemical, and Histological Study)

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Cite This Study

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