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August 5, 2026International Archives of Allergy and Immunology

miR-337-5p targets WNK1 to promote IL-13-induced nasal epithelial inflammation in allergic rhinitis

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Authors

SWShuang WuYXYe XuJQJian Qiao

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Overview

Randomized trial examines miR-337-5p's role in nasal inflammation of allergic rhinitis, suggesting its diagnostic potential.

Key Points

  • This investigation aims to assess the role of plasma miR-337-5p in allergic rhinitis and its targeting of WNK1 during inflammation.
  • RT-qPCR quantified plasma miR-337-5p in 100 allergic rhinitis patients and 100 controls.
  • ROC curve analysis established the diagnostic value of miR-337-5p.
  • In vitro experiments involved IL-13 exposure in HNEpC cells to model Th2-type inflammation.
  • AR patients had significantly higher plasma miR-337-5p, correlating with TNSS scores and eosinophil counts.
  • ROC curve analysis showed an AUC of 0.840 for miR-337-5p as a diagnostic biomarker.
  • Overexpression of miR-337-5p worsened cell injury, apoptosis, and inflammatory cytokine release in IL-13-stimulated HNEpC cells.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a72e823226790f370657c23https://doi.org/10.1159/000553284
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