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This study aims to investigate cortical morphometry changes over time following traumatic brain injury (TBI) using MRI imaging techniques.

August 5, 2026NeuroradiologyOpen Access

MRI-based cortical morphometry in traumatic brain injury: a pilot longitudinal study

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Pilot longitudinal study investigates cortical morphometry changes post-TBI, highlighting potential neuroplasticity implications.

This study aims to investigate cortical morphometry changes over time following traumatic brain injury (TBI) using MRI imaging techniques.
Longitudinal analysis of cortical morphometry using 4 mm Axial MRI scans.
Regions of interest were grouped into cortical lobes including frontal, parietal, and occipital lobes.
Compared TBI group to age/sex matched controls for cortical thickness, surface area, and volume.
Significant cortical thinning observed in the left occipital cortex and right cingulate gyrus over time in TBI group.
Increased cortical thickness in the left insula at the initial TBI scan compared to controls; caution advised due to possible artefacts.
No significant changes in cortical surface area or volume across measured regions after corrections.

Boulton et al. (2026) studied this question.

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