What question did this study set out to answer?

This study aims to evaluate specific and total grass pollen IgE levels in nasal secretions of patients with suspected local allergic rhinitis.

Timothy Grass Pollen-Specific Immunoglobulin E in Nasal Secretions During Natural Allergen Exposure and After a Nasal Provocation Test in Patients with Suspected Local Allergic Rhinitis

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Randomized trial evaluates sIgE levels during allergen exposure in suspected LAR patients, suggesting diagnostic utility.

This study aims to evaluate specific and total grass pollen IgE levels in nasal secretions of patients with suspected local allergic rhinitis.
Included 29 subjects (18 with suspected LAR, 11 with AR)
Used total nasal symptom score (TNSS) and visual analog scale (VAS) for assessment
Performed nasal provocation test (NPT) with grass pollen allergen
TNSS and VAS were significantly higher in LAR during the exposure period (p < 0.0001 and p = 0.0061)
sIgE and total IgE were higher in the AR group compared to LAR during exposure (p = 0.0008 and p = 0.0491)
Median relative sIgE levels were higher after positive and negative provocation (p = 0.0156 and p = 0.0143)

Mortada et al. (2026) studied this question.

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