Why the study?
Does abrupt discontinuation of long-term warfarin therapy increase the incidence of thrombotic events compared to gradual tapering in patients following myocardial infarction?
Population
n=134 patients on long-term anticoagulant therapy (warfarin) following myocardial infarction
Comparison
Abrupt discontinuation of long-term warfarin… vs Gradual tapering of long-term warfarin therapy…
Design
Cohort
Follow-up
6 weeks
Authors
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Abrupt warfarin stop was not associated with excess thrombotic events post-MI; leaves open whether tapering confers benefit in other populations.
Does abrupt discontinuation of long-term warfarin therapy increase the incidence of thrombotic events compared to gradual tapering in patients following myocardial infarction?
Abrupt discontinuation of long-term warfarin therapy following myocardial infarction does not appear to increase the risk of rebound thrombosis compared to gradual tapering.
ROBERT VAN CLEVE (1965) studied this question.
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