Key result
Astrocytes and microglia display distinct phenotypic differences driving antigen presentation to CNS CD4+ T cells.
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The central nervous system has the capacity to initiate and regulate immune responses by allowing restricted entry of peripheral immune cells and providing a microenvironment that is conducive to the activation of immune effector cells. In this commentary, we discuss the ability of two glial cell types, astrocytes and microglia, to function as APCs. In particular, we focus on the phenotypic and functional distinctions between astrocytes and microglia that may contribute to their differing abilities to effectively present Ag to CD4+ cells.
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Shrikant et al. (1996) conducted an editorial in Central nervous system immune response and antigen presentation. Astrocytes and microglia exhibit phenotypic and functional distinctions that contribute to their differing abilities to present antigen to CD4+ T cells in the central nervous system.
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