Why the study?
Does an LPS bolus alter muscle sympathetic nerve activity and cardiovascular regulation in young, healthy volunteers?
Population
18 young, healthy volunteers
Comparison
LPS bolus (4 ng/kg body wt) vs Placebo (saline)
Design
RCT, randomly received
Follow-up
90 min
Authors
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LPS suppresses MSNA and raises heart rate in healthy volunteers; extends RCT evidence on sympathetic and baroreflex changes in experimental endotoxemia.
Does an LPS bolus alter muscle sympathetic nerve activity and cardiovascular regulation in young, healthy volunteers?
Experimental endotoxemia in healthy humans rapidly suppresses postsynaptic sympathetic nerve activity to the muscle vascular bed and alters baroreflex function, providing insight into the cardiovascular effects of early sepsis.
Sayk et al. (2008) studied this question.
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