Population
Cells infected with Coxsackievirus
Comparison
Viral protease 3C(pro) cleavage of IkappaBalpha vs Cells with reduced IkappaBalpha expression
Design
Preclinical
Authors
Loading...
Should not inform clinical management of viral myocarditis; leaves open relevance of this apoptotic mechanism in human disease.
Cleavage of host proteins by pathogen proteases, specifically IkappaBalpha by Coxsackievirus 3C(pro), is a novel mechanism for host recognition and apoptotic response to viral infection.
Zaragoza et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: