What question did this study set out to answer?

This study aims to evaluate the impact of propranolol and phentolamine on heart damage following subarachnoid haemorrhage.

October 7, 1978BMJOpen Access

Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage.

View Full Paper

Ask AI

Bookmark

Why the study?

Does propranolol and phentolamine prevent myocardial necrosis in patients with subarachnoid haemorrhage?

Population

90 patients with subarachnoid haemorrhage (SAH)

Comparison

Propranolol 80 mg eight-hourly plus phentolamine… vs Placebo

Design

RCT, Randomised, Double-blind

Follow-up

3 weeks

Authors

GNG. Neil‐DwyerEssex Cardiothoracic Centre PWP. WalterMedizinische Hochschule Hannover JCJ. M. CruickshankAstraZeneca (United Kingdom)

Discussion

Member takes

Implication

Supports adrenergic blockade in subarachnoid hemorrhage to mitigate cardiac injury; reinforces cardioprotection against catecholamine-mediated necrosis.

Key Points

This study aims to evaluate the impact of propranolol and phentolamine on heart damage following subarachnoid haemorrhage.
90 patients were evaluated, with treatment consisting of propranolol 80 mg and phentolamine 20 mg for three weeks.
The study included an open pilot and a randomized double-blind placebo-controlled design.
Postmortem examinations were conducted on 12 patients to assess myocardial lesions.
All six patients who died while taking placebo exhibited necrotic myocardial lesions, with abnormal ECGs.
No myocardial lesions were found in patients receiving propranolol and phentolamine, all previously having normal ECGs.
Propranolol demonstrated a cardioprotective effect against catecholamine-induced myocardial necrosis.

Structured PICO

Does propranolol and phentolamine prevent myocardial necrosis in patients with subarachnoid haemorrhage?

Population

90 patients with subarachnoid haemorrhage (SAH)

Intervention

Propranolol 80 mg eight-hourly plus phentolamine 20 mg three-hourly by mouth for three weeks

Comparator

Placebo

Outcome

Myocardial necrosis (assessed at postmortem)surrogate

Propranolol and phentolamine appear to prevent catecholamine-induced myocardial necrosis in patients with subarachnoid haemorrhage.

Cite This Study

Neil‐Dwyer et al. (1978) studied this question.

synapsesocial.com/papers/6a72f01a8ff5ffa3ad7489b2 https://doi.org/10.1136/bmj.2.6143.990

View Full Paper

Ask AI

Bookmark

Implication

Supports adrenergic blockade in subarachnoid hemorrhage to mitigate cardiac injury; reinforces cardioprotection against catecholamine-mediated necrosis.

Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider