Why the study?
Do long-chain acylcarnitines induce Ca2+ efflux from the sarcoplasmic reticulum in rabbit left ventricular myocardium?
Population
Sarcoplasmic reticulum (SR)-enriched membrane fractions prepared from rabbit left ventricular myocardium
Comparison
Long-chain acylcarnitines vs Absence of long-chain acylcarnitines, shorter…
Design
Preclinical
Authors
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Findings in rabbit SR vesicles warrant no clinical change; leaves open a mechanistic role in ischemic Ca2+ dysregulation.
Do long-chain acylcarnitines induce Ca2+ efflux from the sarcoplasmic reticulum in rabbit left ventricular myocardium?
Long-chain acylcarnitines enhance Ca2+ release from cardiac SR vesicles independently of ryanodine receptor binding, suggesting a mechanism for electrophysiologic derangements during ischemia.
Yamada et al. (2000) studied this question.
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