What question did this study set out to answer?

Discuss the endogenous checkpoints and biochemical pathways required to mount an effective acute inflammatory response and prevent the transition to chronic inflammation.

December 8, 2006International Journal of Experimental PathologyOpen Access

Chronic inflammation: a failure of resolution?

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Authors

TLToby LawrenceCentre National de la Recherche Scientifique DGDerek W. GilroyAge UK

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Implication

Narrative review reveals endogenous checkpoints governing inflammatory resolution, indicating that chronic inflammation arises from failed termination of innate immune responses.

Key Points

Discuss the endogenous checkpoints and biochemical pathways required to mount an effective acute inflammatory response and prevent the transition to chronic inflammation.
Reviewed physiological mechanisms governing the initiation and endogenous resolution of acute innate inflammation.
Evaluated biochemical pathways responsible for restoring tissue structure and function while preventing persistent tissue injury.
Acute innate inflammatory responses typically initiate within minutes and undergo resolution within hours under coordinated control.
Impairment of endogenous anti-inflammatory resolution pathways causes inflammation to persist for weeks, months, or years, leading to sustained tissue injury.

Cite This Study

Lawrence et al. (2006) studied this question.

synapsesocial.com/papers/6a72f270c94dd74093748c8f https://doi.org/10.1111/j.1365-2613.2006.00507.x

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Implication

Narrative review reveals endogenous checkpoints governing inflammatory resolution, indicating that chronic inflammation arises from failed termination of innate immune responses.

Chronic inflammation: a failure of resolution?

Discussion

Member takes

Implication

Key Points

Cite This Study

Chronic inflammation: a failure of resolution?

Discussion

Member takes

Implication

Key Points

Cite This Study

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