January 1, 2021EXPERIMENTAL ANIMALSOpen Access

Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac function

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Why the study?

Myocardial infarction is a common cardiovascular disease with high morbidity and mortality, prompting investigation into the role of IFIT3 in MI.

Does lentivirus-mediated RNA interference of IFIT3 expression reduce inflammatory response and myocardial fibrosis in mice with myocardial infarction?

Population

Mice with MI induced by LAD coronary artery ligation

Comparison

Lentivirus-mediated RNA interference of IFIT3 vs control

Design

Preclinical animal study

Follow-up

4 weeks

Authors

JSJianhua SunChinese Academy of Sciences QZQi ZhangFudan University Shanghai Cancer Center XLXiaokun LiuQingdao University

Discussion

Member takes

Implication

Does not support IFIT3 targeting in clinical MI care; leaves open therapeutic translation from rodent models.

Structured PICO

Does lentivirus-mediated RNA interference of IFIT3 expression reduce inflammatory response and myocardial fibrosis in mice with myocardial infarction?

Population

Mice with myocardial infarction induced by ligation of the left anterior descending coronary artery

Intervention

Lentivirus-mediated RNA interference of IFIT3 expression via tail vein injection 72 hours before MI modeling

Outcome

Cardiac injury indexes (cTnI, CK-MB) and inflammatory response at 3 days; cardiac function indexes, infarct size, and cardiac fibrosis at 4 weekssurrogate

Knockdown of IFIT3 protects against myocardial injury, inflammation, and fibrosis following myocardial infarction in a mouse model, potentially by blocking the MAPK pathway.

Cite This Study

Sun et al. (2021) studied this question.

synapsesocial.com/papers/6a72f314bfabfe3aef60db70 https://doi.org/10.1538/expanim.21-0060

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Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Downregulation of interferon-induced protein with tetratricopeptide repeats 3 relieves the inflammatory response and myocardial fibrosis of mice with myocardial infarction and improves their cardiac function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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